Sneppen, K., and Ringrose, L. (2019). Theoretical analysis of Polycomb-Trithorax systems predicts that poised chromatin is bistable and not bivalent. Nature Communications 10, Article number: 2133 (Link to article)

Ringrose, L., (2017). Noncoding RNAs in Polycomb and Trithorax Regulation: A Quantitative Perspective. Annu Rev Genet 51:385-411 (Abstract)

Ringrose, L., Howard, M. (2017). Dissecting chromatin-mediated gene regulation and epigenetic memory through mathematical modelling. Current Opinion in Systems Biology 3:7-14. (Abstract)

Ringrose, L. (2017). Epigenetics and Systems Biology. 1st Edition. Academic Press. (Contents & purchase)



Asaoka, T., Almagro, J., Ehrhardt, C., Tsai, I., Schleiffer, A., Deszcz, L., Junttila, S., Ringrose, L., Mechtler, K., Kavirayani, A., Gyenesei, A., Hofmann, K., Duchek, P., Rittinger, K., Ikeda, F. (2016). Linear ubiquitination by LUBEL has a role in Drosophila heat stress response. EMBO Rep. 17(11):1624-1640. (PubMed abstract)

Bauer, M., Trupke, J., Ringrose, L. (2016). The quest for mammalian Polycomb response elements: are we there yet? Chromosoma. 125(3):471-96 (PubMed abstract)


Ringrose, L. (2015). Reconciling randomness and precision. Nat Rev Mol Cell Biol. 16(11):642 (PubMed abstract)

Clevers, H., Firestein, S., Ringrose, L., Bernards, R., Darwin, KH., Vance, RE. (2015). Radical
Sabbaticals. Cell. 163(4):788-9 (PubMed abstract)


Herzog, VA., Lempradl, A., Trupke, J., Okulski, H., Altmutter, C., Ruge, F., Boidol, B., Kubicek, S., Schmauss, G., Aumayr, K., Ruf, M., Pospisilik, A., Dimond, A., Senergin, HB., Vargas, ML., Simon, JA., Ringrose, L. (2014). A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet. 46(9):973-81 (PubMed abstract)
Steffen, PA., Ringrose, L. (2014). What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory. Nat Rev Mol Cell Biol. 15(5):340-56 (PubMed abstract)


Steffen, PA., Fonseca, JP., Gänger, C., Dworschak, E., Kockmann, T., Beisel, C., Ringrose, L. (2013). Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin. Nucleic Acids Res. 41(10):5235-50 (PubMed abstract)


Fonseca, JP., Steffen, PA., Müller, S., Lu, J., Sawicka, A., Seiser, C., Ringrose, L. (2012). In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells. Genes Dev. 26(8):857-71 (PubMed abstract)
Hekimoglu-Balkan, B., Aszodi, A., Heinen, R., Jaritz, M., Ringrose, L. (2012). Intergenic Polycomb target sites are dynamically marked by non-coding transcription during lineage commitment. RNA Biol. 9(3):314-25 (PubMed abstract)
Steffen, PA., Fonseca, JP., Ringrose, L. (2012). Epigenetics meets mathematics: towards a quantitative understanding of chromatin biology. Bioessays. 34(10):901-13 (PubMed abstract)
vandenBerg, A., Ringrose, L. (2012). First annual meeting of the EpiGeneSys Network of Excellence: moving epigenetics towards systems biology. Bioessays. 34(7):620-5 (PubMed abstract)


Okulski, H., Druck, B., Bhalerao, S., Ringrose, L. (2011). Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment. Epigenetics Chromatin. 4:4 (PubMed abstract)
Strübbe, G., Popp, C., Schmidt, A., Pauli, A., Ringrose, L., Beisel, C., Paro, R. (2011). Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A. 108(14):5572-7 (PubMed abstract)


Ringrose, L. (2010). How do RNA sequence, DNA sequence, and chromatin properties regulate splicing? F1000 Biol Rep. 2:74 (PubMed abstract)


Hekimoglu, B., Ringrose, L. (2009). Non-coding RNAs in polycomb/trithorax regulation. RNA Biol. 6(2):129-37 (PubMed abstract)

Ringrose, L. (2009). Transgenesis in Drosophila melanogaster. Methods Mol Biol. 561:3-19 (PubMed abstract)


Hauenschild, A., Ringrose, L., Altmutter, C., Paro, R., Rehmsmeier, M. (2008). Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol. 6(10):e261 (PubMed abstract)

Lempradl, A., Ringrose, L. (2008). How does noncoding transcription regulate Hox genes? Bioessays. 30(2):110-21 (PubMed abstract)


Ringrose, L. (2007). Polycomb comes of age: genome-wide profiling of target sites. Curr Opin Cell Biol. 19(3):290-7 (PubMed abstract)

Ringrose, L., Paro, R. (2007). Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development. 134(2):223-32 (PubMed abstract)


Ringrose, L. (2006). Polycomb, trithorax and the decision to differentiate. Bioessays. 28(4):330-4 (PubMed abstract)


Lee, N., Maurange, C., Ringrose, L., Paro, R. (2005). Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature. 438(7065):234-7 (PubMed abstract)


Ringrose, L., Ehret, H., Paro, R. (2004). Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell. 16(4):641-53 (PubMed abstract)
Ringrose, L., Paro, R. (2004). Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet. 38:413-43 (Pubmed abstract)


Ringrose, L., Rehmsmeier, M., Dura, JM., Paro, R. (2003). Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Dev Cell. 5(5):759-71 (Pubmed abstract)


Ringrose, L., Paro, R. (2001). Gene regulation. Cycling silence. Nature. 412(6846):493-4 (Pubmed abstract)
Ringrose, L., Paro, R. (2001). Remembering silence. Bioessays. 23(7):566-70 (Pubmed abstract)


Ringrose, L., Chabanis, S., Angrand, PO., Woodroofe, C., Stewart, AF. (1999). Quantitative comparison of DNA looping in vitro and in vivo: chromatin increases effective DNA flexibility at short distances. EMBO J. 18(23):6630-41 (Pubmed abstract)


Ringrose, L., Lounnas, V., Ehrlich, L., Buchholz, F., Wade, R., Stewart, AF. (1998). Comparative kinetic analysis of FLP and cre recombinases: mathematical models for DNA binding and recombination. J Mol Biol. 284(2):363-84 (Pubmed abstract)


Ringrose, L. (1997). Biochemical analysis of the site specific recombinases of yeasts and of bacteriophage P1. PhD thesis, EMBL laboratory.
Ringrose, L., Angrand, PO., Stewart, AF. (1997). The Kw recombinase, an integrase from Kluyveromyces waltii. Eur J Biochem. 248(3):903-12 (Pubmed abstract)


Buchholz, F., Ringrose, L., Angrand, PO., Rossi, F., Stewart, AF. (1996). Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res. 24(21):4256-62 (Pubmed abstract)