Epigenetic regulation by the Polycomb and Trithorax group proteins
How do different cell types remember their identities over many cell generations? Part of the answer lies in the Polycomb and Trithorax groups of proteins. The Polycomb (PcG) and Trithorax (TrxG) groups of proteins work antagonistically on the same target genes, to maintain repressed (PcG) or active (TrxG) transcription states. We use a combination of quantitative live imaging, mathematical modelling, computational approaches and molecular and developmental biology to understand the interaction of the Polycomb and Trithorax proteins with their chromatin targets. We aim to unravel this fascinating epigenetic gene regulatory system in terms of the design, function and dynamic behaviour of its components. Our goal is to understand how a system whose components are in constant flux can ensure both stability and flexibility of gene expression states.
L. Ringrose was a founding member and workpackage coordinator of the recent EU FP7 NoE "Epigenesys"