Epigenetic regulation by the Polycomb and Trithorax group proteins


How do different cell types remember their identities over many cell generations? Part of the answer lies in the Polycomb and Trithorax groups of proteins. The Polycomb (PcG) and Trithorax (TrxG) groups of proteins work antagonistically on the same target genes, to maintain repressed (PcG) or active (TrxG) transcription states. We use a combination of quantitative live imaging, mathematical modelling, computational approaches and molecular and developmental biology to understand the interaction of the Polycomb and Trithorax proteins with their chromatin targets. We aim to unravel this fascinating epigenetic gene regulatory system in terms of the design, function and dynamic behaviour of its components. Our goal is to understand how a system whose components are in constant flux can ensure both stability and flexibility of gene expression states.


Cover Epigenetics and Systems Biology.jpg

The first edition of the text book 
"Epigenetics and Systems Biology" (Academic Press) edited by Leonie Ringrose
was published in April 2017.

ISBN: 9780128030752

Find more information here.

Epigenetics: Myths, Mysteries and Molecules

Public Lecture by Leonie Ringrose
A lecture in the Horizons Series Horisontforelesninger.
Arranged by The Faculty of Mathematics and Natural Sciences University of Bergen, Norway

Polycomb and Trithorax in action

Animation of Polycomb and Trithorax proteins in action, courtesy of Vivomotion.

Polycomb and Trithorax animation

Polycomb and Trithorax animation

Epigenesys networK

L. Ringrose was a founding member and workpackage coordinator of the recent EU FP7 NoE "Epigenesys"