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Although it is well known that Polycomb group proteins (PcG) are recruited to cis-regulatory genomic sites, named Polycomb response elements (PREs) in Drosophila melanogaster, the situation in the mouse is less well defined. In this regard, I am particularly interested in the following questions: Do PREs exist in the mouse genome as the global recruiting platform of PcG proteins? Are mouse PREs bistable, switchable elements? Are they involved in maintaining defined cellular identities, for example during murine gonadogenesis? To tackle these questions, I use a combination of high-throughput cloning and next-generation sequencing approaches, followed by in-vivo functional studies. This suite of techniques allows me to validate the mechanistic properties of novel, computationally predicted PREs.