Ringrose, L., Howard, M. (2017). Dissecting chromatin-mediated gene regulation and epigenetic memory through mathematical modelling. Current Opinion in Systems Biology 3:7-14. (Abstract)

Ringrose, L. (2017). Epigenetics and Systems Biology. 1st Edition. Academic Press. (Contents & purchase)

2017


2016

Asaoka, T., Almagro, J., Ehrhardt, C., Tsai, I., Schleiffer, A., Deszcz, L., Junttila, S., Ringrose, L., Mechtler, K., Kavirayani, A., Gyenesei, A., Hofmann, K., Duchek, P., Rittinger, K., Ikeda, F. (2016). Linear ubiquitination by LUBEL has a role in Drosophila heat stress response. EMBO Rep. 17(11):1624-1640. (PubMed abstract)

Bauer, M., Trupke, J., Ringrose, L. (2016). The quest for mammalian Polycomb response elements: are we there yet? Chromosoma. 125(3):471-96 (PubMed abstract)


2015

Ringrose, L. (2015). Reconciling randomness and precision. Nat Rev Mol Cell Biol. 16(11):642 (PubMed abstract)

Clevers, H., Firestein, S., Ringrose, L., Bernards, R., Darwin, KH., Vance, RE. (2015). Radical
Sabbaticals. Cell. 163(4):788-9 (PubMed abstract)


2014

Herzog, VA., Lempradl, A., Trupke, J., Okulski, H., Altmutter, C., Ruge, F., Boidol, B., Kubicek, S., Schmauss, G., Aumayr, K., Ruf, M., Pospisilik, A., Dimond, A., Senergin, HB., Vargas, ML., Simon, JA., Ringrose, L. (2014). A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element. Nat Genet. 46(9):973-81 (PubMed abstract)
 
Steffen, PA., Ringrose, L. (2014). What are memories made of? How Polycomb and Trithorax proteins mediate epigenetic memory. Nat Rev Mol Cell Biol. 15(5):340-56 (PubMed abstract)


2013

Steffen, PA., Fonseca, JP., Gänger, C., Dworschak, E., Kockmann, T., Beisel, C., Ringrose, L. (2013). Quantitative in vivo analysis of chromatin binding of Polycomb and Trithorax group proteins reveals retention of ASH1 on mitotic chromatin. Nucleic Acids Res. 41(10):5235-50 (PubMed abstract)


2012

Fonseca, JP., Steffen, PA., Müller, S., Lu, J., Sawicka, A., Seiser, C., Ringrose, L. (2012). In vivo Polycomb kinetics and mitotic chromatin binding distinguish stem cells from differentiated cells. Genes Dev. 26(8):857-71 (PubMed abstract)
 
Hekimoglu-Balkan, B., Aszodi, A., Heinen, R., Jaritz, M., Ringrose, L. (2012). Intergenic Polycomb target sites are dynamically marked by non-coding transcription during lineage commitment. RNA Biol. 9(3):314-25 (PubMed abstract)
 
Steffen, PA., Fonseca, JP., Ringrose, L. (2012). Epigenetics meets mathematics: towards a quantitative understanding of chromatin biology. Bioessays. 34(10):901-13 (PubMed abstract)
 
vandenBerg, A., Ringrose, L. (2012). First annual meeting of the EpiGeneSys Network of Excellence: moving epigenetics towards systems biology. Bioessays. 34(7):620-5 (PubMed abstract)


2011

Okulski, H., Druck, B., Bhalerao, S., Ringrose, L. (2011). Quantitative analysis of polycomb response elements (PREs) at identical genomic locations distinguishes contributions of PRE sequence and genomic environment. Epigenetics Chromatin. 4:4 (PubMed abstract)
 
Strübbe, G., Popp, C., Schmidt, A., Pauli, A., Ringrose, L., Beisel, C., Paro, R. (2011). Polycomb purification by in vivo biotinylation tagging reveals cohesin and Trithorax group proteins as interaction partners. Proc Natl Acad Sci U S A. 108(14):5572-7 (PubMed abstract)


2010

Ringrose, L. (2010). How do RNA sequence, DNA sequence, and chromatin properties regulate splicing? F1000 Biol Rep. 2:74 (PubMed abstract)
 


2009

Hekimoglu, B., Ringrose, L. (2009). Non-coding RNAs in polycomb/trithorax regulation. RNA Biol. 6(2):129-37 (PubMed abstract)

Ringrose, L. (2009). Transgenesis in Drosophila melanogaster. Methods Mol Biol. 561:3-19 (PubMed abstract)


2008

Hauenschild, A., Ringrose, L., Altmutter, C., Paro, R., Rehmsmeier, M. (2008). Evolutionary plasticity of polycomb/trithorax response elements in Drosophila species. PLoS Biol. 6(10):e261 (PubMed abstract)

Lempradl, A., Ringrose, L. (2008). How does noncoding transcription regulate Hox genes? Bioessays. 30(2):110-21 (PubMed abstract)


2007

Ringrose, L. (2007). Polycomb comes of age: genome-wide profiling of target sites. Curr Opin Cell Biol. 19(3):290-7 (PubMed abstract)

Ringrose, L., Paro, R. (2007). Polycomb/Trithorax response elements and epigenetic memory of cell identity. Development. 134(2):223-32 (PubMed abstract)


2006

Ringrose, L. (2006). Polycomb, trithorax and the decision to differentiate. Bioessays. 28(4):330-4 (PubMed abstract)


2005

Lee, N., Maurange, C., Ringrose, L., Paro, R. (2005). Suppression of Polycomb group proteins by JNK signalling induces transdetermination in Drosophila imaginal discs. Nature. 438(7065):234-7 (PubMed abstract)


2004

Ringrose, L., Ehret, H., Paro, R. (2004). Distinct contributions of histone H3 lysine 9 and 27 methylation to locus-specific stability of polycomb complexes. Mol Cell. 16(4):641-53 (PubMed abstract)
 
Ringrose, L., Paro, R. (2004). Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet. 38:413-43 (Pubmed abstract)


2003

Ringrose, L., Rehmsmeier, M., Dura, JM., Paro, R. (2003). Genome-wide prediction of Polycomb/Trithorax response elements in Drosophila melanogaster. Dev Cell. 5(5):759-71 (Pubmed abstract)


2001

Ringrose, L., Paro, R. (2001). Gene regulation. Cycling silence. Nature. 412(6846):493-4 (Pubmed abstract)
 
Ringrose, L., Paro, R. (2001). Remembering silence. Bioessays. 23(7):566-70 (Pubmed abstract)


1999

Ringrose, L., Chabanis, S., Angrand, PO., Woodroofe, C., Stewart, AF. (1999). Quantitative comparison of DNA looping in vitro and in vivo: chromatin increases effective DNA flexibility at short distances. EMBO J. 18(23):6630-41 (Pubmed abstract)


1998

Ringrose, L., Lounnas, V., Ehrlich, L., Buchholz, F., Wade, R., Stewart, AF. (1998). Comparative kinetic analysis of FLP and cre recombinases: mathematical models for DNA binding and recombination. J Mol Biol. 284(2):363-84 (Pubmed abstract)


1997

Ringrose, L. (1997). Biochemical analysis of the site specific recombinases of yeasts and of bacteriophage P1. PhD thesis, EMBL laboratory.
 
Ringrose, L., Angrand, PO., Stewart, AF. (1997). The Kw recombinase, an integrase from Kluyveromyces waltii. Eur J Biochem. 248(3):903-12 (Pubmed abstract)


1996

Buchholz, F., Ringrose, L., Angrand, PO., Rossi, F., Stewart, AF. (1996). Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res. 24(21):4256-62 (Pubmed abstract)